Chapel Hill, NC 27516 haixuma@live.unc.edu A.1 Estimation of the main effect We briefly discuss how to obtain the estimation of the main effect function M For nonparametric regression, we follow [3] to divide the training data into M folds based on the assigned treatment. Then p ErY |Z, A " as is obtained from the regression forest [4] on Y Z with the dataset tpy We refer to [3] for more discussions about the case of misspecifying the main effect, and the corresponding robust and efficient method to solve the misspecification problem. A.2 Implementation details for the adaptive proximal gradient algorithm Recall that U " diagpX U. In addition, we follow [5] to approximately calculate the proximal operator of P The main steps of the proposed algorithm for SCAF are summarized as below.

The goal of this work was to develop a deep network for whole-head segmentation, including clinical MRIs with abnormal anatomy, and compile the first public benchmark dataset for this purpose. We collected 91 MRIs with volumetric segmentation labels for a diverse set of human subjects (4 normal, 32 traumatic brain injuries, and 57 strokes). These clinical cases are characterized by extended cerebrospinal fluid (CSF) in regions normally containing the brain. Training labels were generated by manually correcting initial automated segmentations for skin/scalp, skull, CSF, gray matter, white matter, air cavity, and extracephalic air. We developed a MultiAxial network consisting of three 2D U-Net models that operate independently in sagittal, axial, and coronal planes and are then combined to produce a single 3D segmentation. The MultiAxial network achieved test-set Dice scores of 0.88 (median plus-minus 0.04). For brain tissue, it significantly outperforms existing brain segmentation methods (MultiAxial: 0.898 plus-minus 0.041, SynthSeg: 0.758 plus-minus 0.054, BrainChop: 0.757 plus-minus 0.125). The MultiAxial network gains in robustness by avoiding the need for coregistration with an atlas. It performed well in regions with abnormal anatomy and on images that have been de-identified. It enables more robust current flow modeling when incorporated into ROAST, a widely-used modeling toolbox for transcranial electric stimulation. We are releasing a state-of-the-art model for whole-head MRI segmentation, along with a dataset of 61 clinical MRIs and training labels, including non-brain structures. Together, the model and data may serve as a benchmark for future efforts.

Mild cognitive impairment (MCI) is a major public health concern due to its high risk of progressing to dementia. This study investigates the potential of detecting MCI with spontaneous voice assistant (VA) commands from 35 older adults in a controlled setting. Specifically, a command-generation task is designed with pre-defined intents for participants to freely generate commands that are more associated with cognitive ability than read commands. We develop MCI classification and regression models with audio, textual, intent, and multimodal fusion features. We find the command-generation task outperforms the command-reading task with an average classification accuracy of 82%, achieved by leveraging multimodal fusion features. In addition, generated commands correlate more strongly with memory and attention subdomains than read commands. Our results confirm the effectiveness of the command-generation task and imply the promise of using longitudinal in-home commands for MCI detection.

The Weighted First-Order Model Counting Problem (WFOMC) asks to compute the weighted sum of models of a given first-order logic sentence over a given domain. It can be solved in time polynomial in the domain size for sentences from the two-variable fragment with counting quantifiers, known as $C^2$. This polynomial-time complexity is also retained when extending $C^2$ by one of the following axioms: linear order axiom, tree axiom, forest axiom, directed acyclic graph axiom or connectedness axiom. An interesting question remains as to which other axioms can be added to the first-order sentences in this way. We provide a new perspective on this problem by associating WFOMC with graph polynomials. Using WFOMC, we define Weak Connectedness Polynomial and Strong Connectedness Polynomials for first-order logic sentences. It turns out that these polynomials have the following interesting properties. First, they can be computed in polynomial time in the domain size for sentences from $C^2$. Second, we can use them to solve WFOMC with all of the existing axioms known to be tractable as well as with new ones such as bipartiteness, strong connectedness, being a spanning subgraph, having $k$ connected components, etc. Third, the well-known Tutte polynomial can be recovered as a special case of the Weak Connectedness Polynomial, and the Strict and Non-Strict Directed Chromatic Polynomials can be recovered from the Strong Connectedness Polynomials, which allows us to show that these important graph polynomials can be computed in time polynomial in the number of vertices for any graph that can be encoded by a fixed $C^2$ sentence and a conjunction of an arbitrary number of ground unary literals.

Recent research has demonstrated the capability of physiological signals to infer both user emotional and attention responses. This presents an opportunity for leveraging widely available physiological sensors in smartwatches, to detect real-time emotional cues in users, such as stress and excitement. In this paper, we introduce SensEmo, a smartwatch-based system designed for affective learning. SensEmo utilizes multiple physiological sensor data, including heart rate and galvanic skin response, to recognize a student's motivation and concentration levels during class. This recognition is facilitated by a personalized emotion recognition model that predicts emotional states based on degrees of valence and arousal. With real-time emotion and attention feedback from students, we design a Markov decision process-based algorithm to enhance student learning effectiveness and experience by by offering suggestions to the teacher regarding teaching content and pacing. We evaluate SensEmo with 22 participants in real-world classroom environments. Evaluation results show that SensEmo recognizes student emotion with an average of 88.9% accuracy. More importantly, SensEmo assists students to achieve better online learning outcomes, e.g., an average of 40.0% higher grades in quizzes, over the traditional learning without student emotional feedback.

In this paper, we consider a multi-stage dynamic assortment optimization problem with multi-nomial choice modeling (MNL) under resource knapsack constraints. Given the current resource inventory levels, the retailer makes an assortment decision at each period, and the goal of the retailer is to maximize the total profit from purchases. With the exact optimal dynamic assortment solution being computationally intractable, a practical strategy is to adopt the re-solving technique that periodically re-optimizes deterministic linear programs (LP) arising from fluid approximation. However, the fractional structure of MNL makes the fluid approximation in assortment optimization highly non-linear, which brings new technical challenges. To address this challenge, we propose a new epoch-based re-solving algorithm that effectively transforms the denominator of the objective into the constraint. Theoretically, we prove that the regret (i.e., the gap between the resolving policy and the optimal objective of the fluid approximation) scales logarithmically with the length of time horizon and resource capacities.

Steerable needles are minimally invasive devices that enable novel medical procedures by following curved paths to avoid critical anatomical obstacles. Planning algorithms can be used to find a steerable needle motion plan to a target. Deployment typically consists of a physician manually inserting the steerable needle into tissue at the motion plan's start pose and handing off control to a robot, which then autonomously steers it to the target along the plan. The handoff between human and robot is critical for procedure success, as even small deviations from the start pose change the steerable needle's workspace and there is no guarantee that the target will still be reachable. We introduce a metric that evaluates the robustness to such start pose deviations. When measuring this robustness to deviations, we consider the tradeoff between being robust to changes in position versus changes in orientation. We evaluate our metric through simulation in an abstract, a liver, and a lung planning scenario. Our evaluation shows that our metric can be combined with different motion planners and that it efficiently determines large, safe start regions.

Learning from point sets is an essential component in many computer vision and machine learning applications. Native, unordered, and permutation invariant set structure space is challenging to model, particularly for point set classification under spatial deformations. Here we propose a framework for classifying point sets experiencing certain types of spatial deformations, with a particular emphasis on datasets featuring affine deformations. Our approach employs the Linear Optimal Transport (LOT) transform to obtain a linear embedding of set-structured data. Utilizing the mathematical properties of the LOT transform, we demonstrate its capacity to accommodate variations in point sets by constructing a convex data space, effectively simplifying point set classification problems. Our method, which employs a nearest-subspace algorithm in the LOT space, demonstrates label efficiency, non-iterative behavior, and requires no hyper-parameter tuning. It achieves competitive accuracies compared to state-of-the-art methods across various point set classification tasks. Furthermore, our approach exhibits robustness in out-of-distribution scenarios where training and test distributions vary in terms of deformation magnitudes.

We present Ego-Exo4D, a diverse, large-scale multimodal multiview video dataset and benchmark challenge. Ego-Exo4D centers around simultaneously-captured egocentric and exocentric video of skilled human activities (e.g., sports, music, dance, bike repair). More than 800 participants from 13 cities worldwide performed these activities in 131 different natural scene contexts, yielding long-form captures from 1 to 42 minutes each and 1,422 hours of video combined. The multimodal nature of the dataset is unprecedented: the video is accompanied by multichannel audio, eye gaze, 3D point clouds, camera poses, IMU, and multiple paired language descriptions -- including a novel "expert commentary" done by coaches and teachers and tailored to the skilled-activity domain. To push the frontier of first-person video understanding of skilled human activity, we also present a suite of benchmark tasks and their annotations, including fine-grained activity understanding, proficiency estimation, cross-view translation, and 3D hand/body pose. All resources will be open sourced to fuel new research in the community.

In this study, we introduce PharmacyGPT, a novel framework to assess the capabilities of large language models (LLMs) such as ChatGPT and GPT-4 in emulating the role of clinical pharmacists. Our methodology encompasses the utilization of LLMs to generate comprehensible patient clusters, formulate medication plans, and forecast patient outcomes. We conduct our investigation using real data acquired from the intensive care unit (ICU) at the University of North Carolina Chapel Hill (UNC) Hospital. Our analysis offers valuable insights into the potential applications and limitations of LLMs in the field of clinical pharmacy, with implications for both patient care and the development of future AI-driven healthcare solutions. By evaluating the performance of PharmacyGPT, we aim to contribute to the ongoing discourse surrounding the integration of artificial intelligence in healthcare settings, ultimately promoting the responsible and efficacious use of such technologies.